Much of our adult behavior reflects the neural circuits sculpted by experience in infancy and early childhood. At no other time in life does the surrounding environment so potently shape brain function – from basic motor skills, sensation or sleep to higher cognitive processes like language. How this plasticity waxes and wanes with age carries an impact far beyond neuroscience, including education policy, therapeutic approaches to developmental disorders or strategies for recovery from brain injury in adulthood.

Our laboratory, housed in the Department of Molecular and Cellular Biology and Center for Brain Science at Harvard University and F.M. Kirby Neurobiology Center at Boston Children’s Hospital, and part of the NIMH-funded Conte Center at Harvard, explores the mechanisms underlying critical periods of brain development. Research is aimed at the interface between cell biology and neuroscience – applying cellular/molecular techniques to elucidate complex neural systems.

Nadine and TakaoHarvard Gazette & SFARI highlight the lab’s recent paper in Neuron
GAZETTE: “Help for halting autism symptoms”>>
SFARI: “Signaling imbalance skews sensory responses in autism”>>

Header based on research image of Luke Bogart, Dawen Cai, Jeff Lichtman & Takao Hensch.
Mouse cartoon to right courtesy of Nadine Gogolla.