Papers

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Reviews & Commentaries | Primary Research Articles

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2017

Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia. Steullet P, Cabungcal JH, Coyle J, Didriksen M, Gill K, Grace AA, Hensch TK, LaMantia AS, Lindemann L, Maynard TM, Meyer U, Morishita H, O’Donnell P, Puhl M, Cuenod M, Do KQ. Mol Psychiatry. 2017 Mar 21 doi: 10.1038/mp.2017.47
Pub Med

Genetic Otx2 Mis-localization delays critical period plasticity across brain regions.
Lee HH, Bernard C, Ye Z, Acampora D, Simeon A, Prochiantz A, DeNardo AA, Hensch TK.
Mol Psychiatry, 2017; 1-9
Pub Med
2016

Trajectory of Parvalbumin Cell Impairment and Loss of Cortical Inhibition in Traumatic Brain Injury
Hsieh T-H, Lee H, Hameed MQ, Pascual-Leone A, Hensch T, Rotenberg A.
Cerebral Cortex,  2016; 1-16
Pub Med

The Power of the Infant Brain
Hensch, TK.
Scientific American. February 2016, 64-69.

Audio

Restoration of Visual Function by Enhancing Conduction in Regenerated Axons.
Bei F, Lee H, Liu X, Gunner G, Jin H, Ma L, Wang C, Hou I, Hensch TK, Frank E,
Sanes JR, Chen C, Fagiolini M, He Z.
Cell. 2016 Jan 14; 164: 219-232.
Journal Link

2015

Remodeling of retrotransposon elements during epigenetic induction of adult visual cortical plasticity by HDAC inhibitors.
Lennartsson A, Arner E, Fagiolini M, Saxena A, Andersson R, Takahashi H, Noro Y, Sng J, Sandelin A, Hensch TK, Carninci P.
Epigenetics Chromatin. 2015 Dec 14;8:55.
PubMed

Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A.
Takei Y, Kikkawa YS, Atapour N, Hensch TK, Hirokawa N.
J Neurosci. 2015 Nov 25;35(47):15539-54.
PubMed

Instructing Perisomatic Inhibition by Direct Lineage Reprogramming of Neocortical Projection Neurons.
Ye Z, Mostajo-Radji MA, Brown JR, Rouaux C, Tomassy GS, Hensch TK, Arlotta P.
Neuron. 2015 Nov 4; 88(3):475-483.
Journal Link

Cell-specific regulation of NMDA receptor maturation by MECP2 in cortical circuits.
Mierau SB, Patrizi A, Hensch TK, Fagiolini M.
Biol Psychiatry. 2015 Jun 5. pii: S0006-3223(15)00467-9.
PubMed

Targeting Oxidative Stress and Aberrant Critical Period Plasticity in the Developmental Trajectory to Schizophrenia.
Do KQ, Cuenod M, Hensch TK.
Schizophr Bull. 2015 Jun 1. pii: sbv065. [Epub ahead of print]
PubMed

Prenatal antidepressant exposure associated with CYP2E1 DNA methylation change in neonates.
Gurnot C, Martin-Subero I, Mah SM, Weikum W, Goodman SJ, Brain U, Werker JF, Kobor MS, Esteller M, Oberlander TF, Hensch TK.
Epigenetics. 2015 Apr 18:1-12. [Epub ahead of print]
PubMed

Clock Genes Control Cortical Critical Period Timing.
Kobayashi Y, Ye Z, Hensch TK.
Neuron. 2015 Apr 8;86(1):264-75.
PubMed

Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons.
Morishita H, Cabungcal JH, Chen Y, Do KQ, Hensch TK.
Biol Psychiatry. 2015 Jan 24. [Epub ahead of print]
PubMed

Critical periods in speech perception: new directions.
Werker JF, Hensch TK.
Annu Rev Psychol. 2015 Jan 3;66:173-96.
PubMed

2014
Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation.
Gogolla N, Takesian AE, Feng G, Fagiolini M, Hensch TK.
Neuron. 2014 Aug 20;83(4):894-905. doi: 10.1016/j.neuron.2014.06.033.
PubMed

Bistable parvalbumin circuits pivotal for brain plasticity.
Hensch TK.
Cell. 2014 Jan 16;156(1-2):17-9.
PubMed

2013
Valproate reopens critical-period learning of absolute pitch.
Gervain J, Vines BW, Chen LM, Seo RJ, Hensch TK, Werker JF, Young AH.
Front. Syst. Neurosci., 2013 Dec 3 | doi: 10.3389/fnsys.2013.00102

Balancing plasticity/stability across brain development.
Takesian AE, Hensch TK.
Prog Brain Res. 2013;207:3-34.
PubMed

Visual acuity development and plasticity in the absence of sensory experience.
Kang E, Durand S, Leblanc JJ, Hensch TK, Chen C, Fagiolini M.
J Neurosci. 2013 Nov 6;33(45):17789-96.
PubMed

Germline recombination by conditional gene targeting with Parvalbumin-Cre lines
Kobayashi Y, Hensch TK.
Frontiers in Neural Circuits. 2013 October.
PubMed

IP3R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice
Hisatsune C, Miyamoto H, Hirono M, Yamaguchi N, Sugawara T, Ogawa N, Ebisui E, Ohshima T, Yamada T, Hensch TK, Hattori M, Mikoshiba1 K.
Frontiers in Neural Circuits. 2013 October.
PubMed

A Theory of the Transition to Critical Period Plasticity: Inhibition Selectively Suppresses Spontaneous Activity.
Toyoizumi T, Miyamoto H, Yazaki-Sugiyama Y, Atapour N, Hensch TK, Miller KD.
Neuron. 2013 Oct 2; 80(1):51-63.
PubMed

DNA methylation map of mouse and human brain identifies target genes in Alzheimer’s disease.
Sanchez-Mut JV, Aso E, Panayotis N, Lott I, Dierssen M, Rabano A, Urdinguio RG, Fernandez AF, Astudillo A, Martin-Subero JI, Balint B, Fraga MF, Gomez A, Gurnot C, Roux JC, Avila J, Hensch TK, Ferrer I, Esteller M.
Brain. 2013 Oct;136(Pt 10):3018-27.
PubMed 

Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome.
Ogiwara I, Iwasato T, Miyamoto H, Iwata R, Yamagata T, Mazaki E, Yanagawa Y, Tamamaki N, Hensch TK, Itohara S, Yamakawa K.
Hum Mol Genet. 2013 Dec 1;22(23):4784-804.
PubMed 

Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity.
Spatazza J, Lee HH, Di Nardo AA, Tibaldi L, Joliot A, Hensch TK, Prochiantz A.
Cell Reports. 2013 Jun 27;3(6):1815-23.
PubMed

Perineuronal nets protect fast-spiking interneurons against oxidative stress.
Cabungcal JH, Steullet P, Morishita H, Kraftsik R, Cuenod M, Hensch TK, Do KQ.
Proc Natl Acad Sci U S A. 2013 May 28;110(22):9130-5.
PubMed

2012
NMDA Receptor Regulation Prevents Regression of Visual Cortical Function in the Absence of Mecp2.
Durand S, Patrizi A, Quast KB, Hachigian L, Pavlyuk R, Saxena A, Carninci P, Hensch TK, Fagiolini M.
Neuron. 2012 Dec 20;76(6):1078-90.
PubMed

Serotonergic Integration of Circadian Clock and Ultradian Sleep-Wake Cycles.
Miyamoto H, Nakamaru-Ogiso E, Hamada K, Hensch TK.
J Neurosci. 2012 Oct 17;32(42):14794-14803.
PubMed

Critical period for acoustic preference in mice.
Yang EJ, Lin EW, Hensch TK.
Proc Natl Acad Sci U S A. 2012 Oct 16;109 Suppl 2:17213-20.
PubMed

Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perception.
Weikum WM, Oberlander TF, Hensch TK, Werker JF.
Proc Natl Acad Sci U S A. 2012 Oct 16;109 Suppl 2:17221-7.
PubMed

A mouse model for too much TV?
Bilimoria PM, Hensch TK, Bavelier D.
Trends Cogn Sci. 2012 Nov;16(11):529-31.
PubMed

Mouse with Na(v)1.1 haploinsufficiency, a model for Dravet syndrome, exhibits lowered sociability and learning impairment.
Ito S, Ogiwara I, Yamada K, Miyamoto H, Hensch TK, Osawa M, Yamakawa K.
Neurobiol Dis. 2012 Aug 16;49C:29-40.
PubMed

Otx2 binding to perineuronal nets persistently regulates plasticity in the mature visual cortex.
Beurdeley M, Spatazza J, Lee HH, Sugiyama S, Bernard C, Di Nardo AA, Hensch TK, Prochiantz A.
J Neurosci. 2012 Jul 4;32(27):9429-37.
PubMed

Trehalose-enhanced isolation of neuronal sub-types from adult mouse brain.
Saxena A, Wagatsuma A, Noro Y, Kuji T, Asaka-Oba A, Watahiki A, Gurnot C, Fagiolini M, Hensch TK, Carninci P.
Biotechniques. 2012 Jun;52(6):381-5.
PubMed

Amblyopia: background to the special issue on stroke recovery.
Maurer D, Hensch TK.
Dev Psychobiol. 2012 Apr;54(3):224-38.
PubMed

2011
A critical period for auditory thalamocortical connectivity.
Barkat TR, Polley DB, Hensch TK.
Nat Neurosci. 2011 Jul 31;14(9):1189-94.
PubMed

Linking topography to tonotopy in the mouse auditory thalamocortical circuit.
Hackett TA, Barkat TR, O’Brien BM, Hensch TK, Polley DB.
J Neurosci. 2011 Feb 23;31(8):2983-95.
PubMed

Excitatory projection neuron subtypes control the distribution of local inhibitory interneurons in the cerebral cortex.
Lodato S, Rouaux C, Quast KB, Jantrachotechatchawan C, Studer M, Hensch TK, Arlotta P.
Neuron. 2011 Feb 24;69(4):763-79.
PubMed

2010
Lynx1, a cholinergic brake, limits plasticity in adult visual cortex.
Morishita H, Miwa JM, Heintz N, Hensch TK.
Science. 2010 Nov 26;330(6008):1238-40.
PubMed

Removing brakes on adult brain plasticity: from molecular to behavioral interventions.
Bavelier D, Levi DM, Li RW, Dan Y, Hensch TK.
J Neurosci. 2010 Nov 10;30(45):14964-71.
PubMed

2009
Common circuit defect of excitatory-inhibitory balance in mouse models of autism.
Gogolla N, Leblanc JJ, Quast KB, Südhof TC, Fagiolini M, Hensch TK.
J Neurodev Disord. 2009 Jun;1(2):172-81.
PubMed

Bidirectional plasticity in fast-spiking GABA circuits by visual experience.
Yazaki-Sugiyama Y, Kang S, Câteau H, Fukai T, Hensch TK.
Nature. 2009 Nov 12;462(7270):218-21.
PubMed

Development. Editorial overview.
Hensch TK, Brand AH.
Curr Opin Neurobiol. 2009 Apr;19(2):109-11.
PubMed

From brain formation to plasticity: insights on Otx2 homeoprotein.
Sugiyama S, Prochiantz A, Hensch TK.
Dev Growth Differ. 2009 Apr;51(3):369-77.
PubMed

Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility.
Suzuki T, Miyamoto H, Nakahari T, Inoue I, Suemoto T, Jiang B, Hirota Y, Itohara S, Saido TC, Tsumoto T, Sawamoto K, Hensch TK, Delgado-Escueta AV, Yamakawa K.
Hum Mol Genet. 2009 Mar 15;18(6):1099-109.
PubMed

2008
A resource for transcriptomic analysis in the mouse brain.
Plessy C, Fagiolini M, Wagatsuma A, Harasawa N, Kuji T, Asaka-Oba A, Kanzaki Y, Fujishima S, Waki K, Nakahara H, Hensch TK, Carninci P.
PLoS One. 2008 Aug 20;3(8):e3012.
PubMed

Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity.
Sugiyama S, Di Nardo AA, Aizawa S, Matsuo I, Volovitch M, Prochiantz A, Hensch TK.
Cell. 2008 Aug 8;134(3):508-20.
PubMed

Critical period revisited: impact on vision.
Morishita H, Hensch TK.
Curr Opin Neurobiol. 2008 Feb;18(1):101-7.
PubMed

2007
Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.
Ogiwara I, Miyamoto H, Morita N, Atapour N, Mazaki E, Inoue I, Takeuchi T, Itohara S, Yanagawa Y, Obata K, Furuichi T, Hensch TK, Yamakawa K.
J Neurosci. 2007 May 30;27(22):5903-14.
PubMed

Optimization of somatic inhibition at critical period onset in mouse visual cortex.
Katagiri H, Fagiolini M, Hensch TK.
Neuron. 2007 Mar 15;53(6):805-12.
PubMed

2005
Excitatory-inhibitory balance and critical period plasticity in developing visual cortex.
Hensch TK, Fagiolini M.
Prog Brain Res. 2005;147:115-24.
PubMed

International perspectives on engaging the public in neuroethics.
Illes J, Blakemore C, Hansson MG, Hensch TK, Leshner A, Maestre G, Magistretti P, Quirion R, Strata P.
Nat Rev Neurosci. 2005 Dec;6(12):977-82.
PubMed

Critical period plasticity in local cortical circuits.
Hensch TK.
Nat Rev Neurosci. 2005 Nov;6(11):877-88.
PubMed

Critical period mechanisms in developing visual cortex.
Hensch TK.
Curr Top Dev Biol. 2005;69:215-37.
PubMed

Recovery in the blink of an eye.
Hensch TK.
Neuron. 2005 Oct 20;48(2):166-8.
PubMed

The transcriptional landscape of the mammalian genome.
Carninci P, et al.
Science. 2005 Sep 2;309(5740):1559-63.
PubMed

2004
Experience-dependent pruning of dendritic spines in visual cortex by tissue plasminogen activator.
Mataga N, Mizuguchi Y, Hensch TK.
Neuron. 2004 Dec 16;44(6):1031-41.
PubMed

Critical period regulation.
Hensch TK.
Annu Rev Neurosci. 2004;27:549-79.
PubMed

Specific GABAA circuits for visual cortical plasticity.
Fagiolini M, Fritschy JM, Löw K, Möhler H, Rudolph U, Hensch TK.
Science. 2004 Mar 12;303(5664):1681-3.
PubMed

Columnar architecture sculpted by GABA circuits in developing cat visual cortex.
Hensch TK, Stryker MP.
Science. 2004 Mar 12;303(5664):1678-81.
PubMed

2003
Reciprocal interaction of sleep and synaptic plasticity.
Miyamoto H, Hensch TK.
Mol Interv. 2003 Oct;3(7):404-17.
PubMed

Subtraction of cap-trapped full-length cDNA libraries to select rare transcripts.
Hirozane-Kishikawa T, Shiraki T, Waki K, Nakamura M, Arakawa T, Kawai J, Fagiolini M, Hensch TK, Hayashizaki Y, Carninci P.
Biotechniques. 2003 Sep;35(3):510-6, 518.
PubMed

Controlling the critical period.
Hensch TK.
Neurosci Res. 2003 Sep;47(1):17-22.
PubMed

Rapid critical period induction by tonic inhibition in visual cortex.
Iwai Y, Fagiolini M, Obata K, Hensch TK.
J Neurosci. 2003 Jul 30;23(17):6695-702.
PubMed

Experience-dependent slow-wave sleep development.
Miyamoto H, Katagiri H, Hensch T.
Nat Neurosci. 2003 Jun;6(6):553-4.
PubMed

Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.
Carninci P, et al.
Genome Res. 2003 Jun;13(6B):1273-89.
PubMed

Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling.
Fagiolini M, Katagiri H, Miyamoto H, Mori H, Grant SG, Mishina M, Hensch TK.
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2854-9.
PubMed

2002
Permissive proteolytic activity for visual cortical plasticity.
Mataga N, Nagai N, Hensch TK.
Proc Natl Acad Sci U S A. 2002 May 28;99(11):7717-21.
PubMed

Experience-dependent plasticity without long-term depression by type 2 metabotropic glutamate receptors in developing visual cortex.
Renger JJ, Hartman KN, Tsuchimoto Y, Yokoi M, Nakanishi S, Hensch TK.
Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):1041-6.
PubMed

2001
Experience-dependent plasticity of mouse visual cortex in the absence of the neuronal activity-dependent marker egr1/zif268.
Mataga N, Fujishima S, Condie BG, Hensch TK.
J Neurosci. 2001 Dec 15;21(24):9724-32.
PubMed

2000
Inhibitory threshold for critical-period activation in primary visual cortex.
Fagiolini M, Hensch TK.
Nature. 2000 Mar 9;404(6774):183-6.
PubMed

1999
Whisking away space in the brain.
Hensch TK.
Neuron. 1999 Nov;24(3):492-3.
PubMed

1998
Local GABA circuit control of experience-dependent plasticity in developing visual cortex.
Hensch TK, Fagiolini M, Mataga N, Stryker MP, Baekkeskov S, Kash SF.
Science. 1998 Nov 20;282(5393):1504-8.
PubMed

Comparison of plasticity in vivo and in vitro in the developing visual cortex of normal and protein kinase A RIbeta-deficient mice.
Hensch TK, Gordon JA, Brandon EP, McKnight GS, Idzerda RL, Stryker MP.
J Neurosci. 1998 Mar 15;18(6):2108-17.
PubMed

1996
Ocular dominance plasticity under metabotropic glutamate receptor blockade.
Hensch TK, Stryker MP.
Science. 1996 Apr 26;272(5261):554-7.
PubMed

Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines.
Luo L, Hensch TK, Ackerman L, Barbel S, Jan LY, Jan YN.
Nature. 1996 Feb 29;379(6568):837-40.
PubMed